Endocrine Abstracts

Introduction: Generally, symptoms of celiac disease is not accompanied when present together with autoimmune endocrine diseases. In this study, we aimed to investigate the prevalence of silent celiac disease in the APS and autoimmune monoglandular disorders by measuring tissue transglutaminase antibodies (ttgAb).Methods: A total of 103 patients with monaglandular or polyglandular autoimmune endocrine disorders and 32 control subjects were enrolled in the...

Introduction: Vitamin D Deficiency has been widely regarded as contributing to autoimmune disease, but low levels of vitamin D in patients with autoimmune disease may be a result rather than a cause like from malabsorbtion due to celiac disease, gastrointestinal disorders related to diabetes or thyroid disease, corticosteroid therapy complications etc\..In this study, we aimed to investigate vitamin d levels in autoimmune endocrine disorders and relationship with silent celiac...

Introduction: Thyroid papillary carcinomas originate from thyroid follicular epithelia and are the most frequent thyroid differentiated carcinomas. Medullary thyroid carcinomas originate from thyroid parafollicular C cells and %25 are a component of Multiple Endocrine Neoplasia (MEN) syndromes. Co-incidence of the two condition on the same patient is so rare.Case: 78 years old female patient who has had simple goiter for 10 years, was investigated about ...

Background: Although very rare, insulinomas are the most commonly occurring endocrine tumor of the pancreas. The aim of this study was to review the clinical presentation, diagnostic approach and management of patients with an insulinoma.Methods: 22 insulinoma patients, with an age range of 20–79, were included and evaluated according to their clinical presentation, blood biochemistry, imaging studies, operative management, pathological manifestatio...

Multiple myeloma is a neoplastic disorder arising from plasma cells in the bone marrow. Plasma cell tumors, plasmacytomas, are uncommon in the brain and occur usually in the leptomeninges with or without parencymal involvement. Extramedullary plasmacytomas are very rarely located in the sella and can be misdiagnosed as a nonfunctioning pituitary adenoma. We report an illustrative case with multiple myeloma who was diagnosed having sellar plasmacytoma resembling a nonfunctionin...

Sex reversal syndrome (SRS) is a kind of human genetic disease about gender dysplasia, which is characterised by inconsistency between gonadal sexuality and chromosome sexuality. The clinical types include 46, XY female SRS and 46, XX male SRS. The early studies of human gonadal differentiation found that human Y chromosome contains testis-determining factor (TDF) found that the sex-determining region Y (SRY) gene, which is located in Y chromosome, was the best candidate gene ...

Aim: To evaluate the relationship between glycemic control and quality of life parameters in patients with poorly controlled type 2 diabetes.Methods: Fifty patients with poorly controlled (HbA1c 8–12%) type 2 diabetes included the study and were answered DQOL and SF-36 questionnaires to an assistant in internal medicine. HbA1c levels, age, gender, duration of diabetes, height, weight and waist–hip ratio measurements recorded at the same time.</...

Aim: To compare the effectiveness of insulin detemir when added to oral antidiabetic drug therapy as a single daily dose or twice daily.Method: Fifty patients with a diagnosis of type 2 diabetes receiving oral antidiabetic drug therapy and glycemic control did not provided were included the study. Insulin detemir was begun 0.1–0.2 U/kg daily dose, half of the patients started with a single daily dose and the other half with same dose twice daily. At...

Introduction: RET mutation analysis has a critical importance for determining clinical approach to hereditary medullary thyroid carcinoma (MTC). The current guidelines recommends to determine the timing of prophylactic thyroidectomy depending on the risk stratification, mainly decided by the type of the mutation.Methods: Society of Endocrinology and Metabolism of Turkey (SEMT) sponsored ret genetic screening between July 2008 and January 2012 in 513 pati...

Introduction: TURK-MEN study was carried out to evaluate the mutational analysis of so called sporadic MTC patients between 1994 and 2005. Our aim was to evaluate the ret genetic screening results, distribution of mutations among so called sporadic and hereditary MTC patients in Turkey between 2008 and 2012.Methods: Society of Endocrinology and Metabolism of Turkey (SEMT) sponsored ret genetic screening between July 2008 and January 2012 in 513 patients....